The royal figure gives up his title as the Duke.
Prince Andrew is relinquishing his designations, including the York's Duke, he has declared in a individual message.
He has been under increasing pressure over his connections with convicted criminal Jeffrey Epstein, with demands for the monarchy to take measures against him.
That now seems to have caused the prince deciding to of his own accord give up his designations and to give up participation of the Garter Order.
In his statement he said he continued to "strongly deny the allegations against me".
"In consultation with the monarch, and my direct and extended family, we have agreed the continued claims about me divert from the duties of the monarch and the Royal Family," said a statement from the royal.
"I have decided, as I always have, to put my duty to my family and country first.
"I support my decision five years ago to step back from official duties.
"With the King's agreement, we feel I must now go a step further. I will therefore no longer use my designation or the honours which have been conferred upon me. As I have said before, I vigorously refute the accusations against me."
Prince Andrew has been involved in a range of issues, such as a lawsuit he ended with the plaintiff, questions about his finances and his involvement with an suspected intelligence operative.
He will remain a prince - but will cease to be the York's Duke, a honor bestowed from his parent, the former monarch.
He had already stopped to be a "participating figure" and had lost the use of his His Royal Highness designation and no longer appeared at public engagements. His status now will be even more diminished.
His ex-wife will be known as Sarah and no longer the Duchess, but their children will carry on to have the honor of princess.
He has faced intense attention over his associations with notorious figure the financier, more lately featuring questions about when he had truly severed communication.
In his media discussion, Prince Andrew had said that he had severed all connections with the financier after they had been seen together in NYC in December 2010.
But correspondence sent in early 2011 later emerged implying that he had privately continued in contact with the financier, such as sending a note: "Remain connected and we'll meet again soon!"
There had been growing displeasure in Buckingham Palace at the scandals that continued to envelop the prince.
Soon a late publication by the accuser will be published which is anticipated to draw more scrutiny on his connection with Ms Giuffre and the financier.