New research reveals that people who discontinue blockbuster slimming jabs like Wegovy and Mounjaro can put back on reduced body mass much more quickly than those who end traditional lifestyle regimens.
Findings released in a prominent health publication demonstrates that while overweight people can lose substantial amounts of their body weight while undergoing treatment, the weight returns at an average rate of 0.8 kg per month after stopping.
"Users buying such drugs must be informed of the potential of fast rebound weight gain when the therapy is stopped," stated lead investigator Dr. Susan Jebb.
This pace of regain suggests a return to starting weight in about one and a half years.
Comparing Therapies
The analysis, which examined 37 of trials involving over 9,000 of patients, compared the outcomes of the injectable medications with conventional dieting.
Scientists emphasize that people who shed pounds through diet and exercise usually have a slower weight regain—approximately 0.1 kg a month—after stopping.
Understanding the Quick Regain
Doctors suggest the mechanism of the drugs accounts for the heightened weight return.
The injections mimic a natural hormone called GLP-1, which helps regulate hunger.
"Artificially providing GLP-1 concentrations far above than normal might result in the body to produce less of its endogenous hormone, and could lessen sensitivity to its actions," explained Dr. Adam Collins, a nutrition expert.
"Stopping of this GLP-1 'fix' leads to hunger is no longer kept in check, making binge eating much more probable."
A Chronic Condition?
The NHS suggest the jabs for individuals with weight-linked medical conditions, accompanied by prescribed lifestyle changes.
A number of clinicians argue that, given the likelihood of relapse, the therapy might need to be life-long.
This opinion is echoed by drug manufacturers, who say that the results "emphasize the chronic character of excess weight," comparing it to managing diseases like diabetes.
Patient Testimonies
People who have discontinued the jabs report a sudden return of hunger.
"It was like a switch flipping and you become ravenous," said a patient.
This difficulty is exacerbated if patients have not established sustainable dietary or behavioural changes during treatment.
Growing Interest
Survey data show that millions of adults in the UK have tried weight-loss jabs in the past year, with desire remaining high.
- Use is greater among females compared to men.
- The 40s and 50s demographic shows the greatest level of interest.
- A large proportion obtain the drugs through private prescriptions rather than the NHS.
Ultimately, clinicians stress that while these medications are potent tools for shedding pounds, they are not a standalone cure and maintained weight loss hinges on integrated behavioural support.
